Browsing by Subject "Cell Movement"
Now showing items 1-7 of 7
-
Article
A dominant-negative provides new insights into FAK regulation and function in early embryonic morphogenesis
(2013)FAK is a non-receptor tyrosine kinase involved in a wide variety of biological processes and crucial for embryonic development. In this manuscript, we report the generation of a new FAK dominant negative (FF), composed of ...
-
Article
Hemodynamics in stenotic vessels of small diameter under steady state conditions: Effect of viscoelasticity and migration of red blood cells
(2015)BACKGROUND: In microcirculation, the non-Newtonian behavior of blood and the complexity of the microvessel network are responsible for the high flow resistance and the large reduction of the blood pressure. Red blood cell ...
-
Article
Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells
(2012)Although pathogenic bacteria are suspected contributors to colorectal cancer progression, cancer-promoting bacteria and their mode of action remain largely unknown. Here we report that sustained infection with the human ...
-
Article
Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy
(1999)The role of the thymus in HIV-1 pathogenesis remains unclear. We developed an assay to quantify the number of recent thymic emigrants in blood based on the detection of a major excisional DNA byproduct (termed α1 circle) ...
-
Article
Polarized distribution of Bcr-Abl in migrating myeloid cells and co-localization of Bcr-Abl and its target proteins
(1999)Bcr-Abl plays a critical role in the pathogenesis of Philadelphia chromosome-positive leukemia. Although a large number of substrates and interacting proteins of Bcr-Abl have been identified, it remains unclear whether ...
-
Article
Recent thymic emigrants and prognosis in T- and B-cell childhood hematopoietic malignancies
(2002)The concentration of T-cell receptor rearrangement excision DNA circles (TRECs) in peripheral blood mononuclear cells (PBMCs) is currently known to be a marker of recent thymic emigrants. We evaluated the hypothesis that ...
-
Article
Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: In silico insights
(2016)Gliomas are highly invasive brain tumours characterised by poor prognosis and limited response to therapy. There is an ongoing debate on the therapeutic potential of vaso-modulatory interventions against glioma invasion. ...